期刊
JOURNAL OF NATURAL MEDICINES
卷 70, 期 1, 页码 45-53出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-015-0935-3
关键词
Anthocyanin; Hepatotoxicity; Alcohol; Oxidation stress; CYP2E1
资金
- High-end Foreign Experts Recruitment Programme of State Administration of Foreign Experts Affairs [GDW20146100228]
- Ministry of Education and State Administration of Foreign Experts Affair Overseas Teacher Project [MS2011XBNL057]
- Key Construction Program of International Cooperation Base in S&T, Shaanxi Province, China [2015SD0018]
- Shannxi Provincial Science and Technology Coordinating innovative engineering project [2013ZDGC-04]
Alcoholic liver disease (ALD) is a serious and challenging health issue. In the past decade, natural components possessing hepatoprotective properties have gained more attention for ALD intervention. In this study, the phytochemical components of anthocyanins from purple potato were assessed using UPLC-MS/MS, and the hepatoprotective effects of purple potato anthocyanins (PPAs) were investigated in the ALD mouse model. Serum and liver biochemical parameters were determined, along with histopathological changes in liver tissue. In addition, the major contributors to alcohol-induced oxidative stress were assessed. The results indicated that the levels of aspartate transaminase and alanine transaminase were lower in the serum of the PPA-treated group than the alcohol-treated group. PPAs significantly inhibited the reduction of total cholesterol and triglycerides. Higher levels of superoxide dismutase and reduced glutathione enzymes as well as a reduction in the formation of malondialdehyde occurred in mice fed with PPAs. In addition, PPAs protected against increased alcohol-induced levels and activity of cytochrome P450 2E1 (CYP2E1), which demonstrates the effects of PPAs against alcohol-induced oxidative stress and liver injury. This study suggests that PPAs could be an effective therapeutic agent in alcohol-induced liver injuries by inhibiting CYP2E1 expression and thereby strengthening antioxidant defenses.
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