期刊
CRITICAL REVIEWS IN TOXICOLOGY
卷 43, 期 7, 页码 580-606出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10408444.2013.808172
关键词
Biphasic; cell signaling; dose-response; hormesis; hormetic; receptor-mediated mechanism; U-shaped
类别
资金
- Richard Lounsbery Foundation
- ExxonMobil Foundation
- Air Force Office of Scientific Research, Air Force Material Command, USAF [FA9550-07-1-0248]
This article provides the first extensive documentation of mechanisms of hormetic dose/concentration responses. The mechanisms selected were principally those mediated via receptor and/or cell signaling pathways. Mechanisms are reported for greater than 100 agents affecting nearly 400 dose/concentration responses from a wide range of chemical classes, affecting a broad range of cell types and endpoints. Regardless of the model (i.e. in vitro or in vivo), inducing agent, endpoint, or receptor/cell signaling pathway mediated mechanism, the quantitative features of the hormetic dose/concentration responses are similar, suggesting that the magnitude of the response is a measure of biological plasticity, within a broad range of biological contexts. These findings represent an important advance in the understanding of the hormetic dose/concentration response, its generalizability and potential biomedical applications, including drug discovery/efficacy assessment and the risk assessment process.
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