期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 130, 期 -, 页码 70-77出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2018.06.019
关键词
Cholestasis; Drug-induced liver injury; Hepatotoxicity; Chemotherapy; S-adenosylmethionine
资金
- Abbott Products Operations AG, Switzerland
Drug-induced liver injury (DILI) remains the most common cause of acute liver failure in the Western world. Chemotherapy is one of the major class of drugs most frequently associated with idiosyncratic DILI. For this reason, patients who receive chemotherapy require careful assessment of liver function prior to treatment to determine which drugs may not be appropriate and which drug doses should be modified. S-adenosylmethionine (SAMe) is an endogenous agent derived from methionine. Its supplementation is effective in the treatment of liver disease, in particular intrahepatic cholestasis (IHC). The target of this review is to analyze the mechanisms of hepatotoxicity of the principal anticancer agents and the role of SAMe in the prevention of this complication.
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