期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 82, 期 3, 页码 378-386出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2011.08.005
关键词
Sorafenib; Cutaneous adverse events; Hand-foot skin reaction; Prevention; Guidelines; Targeted therapy
资金
- Bayer Italy
Cutaneous adverse events commonly reported with tyrosine kinase inhibitors (TKIs) in the treatment of malignancies, represent an important clinical concern since they can limit the optimal use of these novel drugs. Although there are numerous reports in the literature of these events there are no practical guidelines on how they should be managed. The Sorafenib Working Group (SWG) was established with the objective of developing recommendations to allow the early detection, prevention and management of cutaneous adverse events in everyday clinical practice. The SWG was a multidisciplinary team made up of experts in the field who were closely involved in the sorafenib clinical development program. This review provides an overview of the nature and incidence of cutaneous adverse events which manifest with sorafenib treatment and provides recommendations for their early detection and effective management in clinical practice. (c) 2011 Elsevier Ireland Ltd. All rights reserved.
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