期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 84, 期 -, 页码 E49-E57出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2010.09.002
关键词
Breast cancer; Growth factor; Kinase inhibitor; Oncogene; Monoclonal antibody; Receptor tyrosine kinase
资金
- NCI NIH HHS [R01 CA072981-04, R37 CA072981, 4R37CA072981, R01 CA072981] Funding Source: Medline
The receptor tyrosine kinasc HER2 is overexpresscd in approximately 25% of breast cancers. HER2 acts as a signal amplifier for its siblings, namely three different transmembrane receptors that collectively bind with II distinct growth factors of the EGF family. Thus, overexpression of HER2 confers aggressive invasive growth in preclinical models and in patients. Specific therapies targeting HER2 include monoclonal antibodies, antibody-drug conjugates, small molecule tyrosine kinase inhibitors, as well as heat shock protein and sheddase inhibitors. Two of these drugs have shown impressive - yet mostly transient - efficacy in patients with HER2 overexpressing breast cancer. We highlight the biological roles of HER2 in breast cancer progression, and overview the available therapeutic armamentarium directed against this receptor-kinase molecule. Focusing on the mechanisms that confer resistance to individual HER2 targeting agents, we envisage therapeutic approaches to delay or overcome the evolvement of resistance in patients. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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