期刊
CRITICAL REVIEWS IN IMMUNOLOGY
卷 34, 期 4, 页码 301-314出版社
BEGELL HOUSE INC
DOI: 10.1615/CritRevImmunol.2014009988
关键词
AICD; T cells; Fas; FasL; peripheral tolerance; autoimmunity
类别
资金
- Grants-in-Aid for Scientific Research [25670798, 24689068] Funding Source: KAKEN
Activation-induced cell death (AICD) of T cells is a process for regulating the peripheral immune system. The fate of a T cell is controlled by numerous signals derived from various stimuli, such as antigens, cytokines, and chemokines. In healthy humans, overactivated or autoreactive T cells are harmful and are eliminated to maintain the immune system. AICD in T cells by Fas/FasL-mediated apoptosis is triggered by the switch from life to death through several signaling molecules. The control or distribution of Fas or FasL expression largely affects AICD of T cells. Although autoimmune diseases are considered to be induced by multiple factors, an impaired immune system with AICD by Fas/FasL-mediated apoptosis leads to the onset or development of autoimmunity. Based on published reports, this review describes the regulatory mechanisms involved in AICD of T cells by Fas/FasL-mediated apoptosis and the associations between AICD and autoimmunity in humans and animal models.
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