期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 15, 期 6, 页码 4224-4228出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2015.9613
关键词
Bovine Viral Diarrhea Virus (BVDV); HCV Surrogate Model; 1-Indanone Thiosemicarbazones; Hydroxypropyl-beta-Cyclodextrin Inclusion Complexes; Direct-Acting Antiviral Agents
类别
资金
- CONICET [PIP0220]
The current standard of care of the infection by hepatitis C virus (HCV) is effective in a limited number of patients and the high cost hinders therapy affordability and compliance. In this context, the research of new direct-acting antiviral agents (DAAs) for a more effective and long-lasting therapy is an urgent need and an area of active investigation. In an effort to develop novel DAAs, a series of 1-indanone thiosemicarbazones (TSCs) was synthesized and fully characterized. However, the high self-aggregation tendency and extremely poor aqueous solubility of these antiviral candidates often preclude their reliable biological evaluation in vitro. To maintain constant TSC concentrations over the biological assays, different TSC/cyclodextrin complexes were produced. In the present work, we report for the first time the cytotoxicity and antiviral activity of 5,6-dimethoxy TSC inclusion complexes with hydroxypropyl-beta-cyclodextrin on bovine viral diarrhea virus (BVDV) as HCV surrogate model. Results showed a potent suppression of the virus replication, with greater activity for the inclusion complexes than the free compound.
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