期刊
CRITICAL REVIEWS IN IMMUNOLOGY
卷 34, 期 6, 页码 517-536出版社
BEGELL HOUSE INC
DOI: 10.1615/CritRevImmunol.2014012204
关键词
dendritic cells; dendritic cell-based cancer vaccines; natural killer cells; natural killer T cells; gamma delta T cells
类别
资金
- NWO-VICI [91814655]
- Dutch Cancer Society [KUN2013-5958]
- Radboud University Medical Center Ph.D. grant
- Swedish research council
Dendritic cells (DCs) are key players in the induction of immune responses. Adoptive transfer of autologous mature DCs loaded with tumor-associated antigens is a promising therapy for the treatment of immunogenic tumors. For a long time, its therapeutic activity was thought to depend solely on the induction of tumor-specific CD8(+) and CD4(+) T cell responses. More recently, DCs were shown to bidirectionally interact with innate and innate-like immune cells, including natural killer (NK), invariant natural killer T (iNKT), and gamma delta T cells. These effector cells can amplify responses induced by DCs via several mechanisms, including induction of DC maturation and conventional T cell priming. In addition, NK, iNKT, and gamma delta T cells possess cytolytic activity and can act directly on tumor cells. Therapeutic strategies targeting these innate and innate-like immune cells hence hold potential to improve current DC vaccination protocols.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据