期刊
CRITICAL REVIEWS IN IMMUNOLOGY
卷 34, 期 2, 页码 91-102出版社
BEGELL HOUSE INC
DOI: 10.1615/CritRevImmunol.2014010183
关键词
Immunosurveillance; evasion; phenotypic plasticity; tumor microenvironment; EMT
类别
资金
- Ligue contre le Cancer
- Institut National du Cancer (INCa)
- Association de Recherche sur le Cancer
- INSERM
- Public Research Center for Health, Luxembourg
- Fondation Cancer, Luxembourg
- Agency for Science Research and Technology A*STAR
- School of Medicine National University of Singapore
Since tumor cell plasticity was first shown to be crucial in tumor promotion and immune surveillance evasion, it has become an issue of intense investigation. Several mechanisms are associated with the acquisition of tumor cell plasticity and immune evasion, including loss of epithelial phenotype through epithelial-to-mesenchymal transition (EMT). We discuss recent evidence revealing that tumor cell plasticity may lead to the emergence of immunoresistant variants and how the tumor microenvironment evolves to shape this plasticity We argue that targeting carcinoma cell plasticity represents a novel strategy to better control the emergence of resistant variants and to ensure more effective cancer therapies. In this context, the design of innovative integrative immunotherapy approaches is warranted.
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