期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 15, 期 6, 页码 4136-4142出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2015.9602
关键词
Mesenchymal Stem Cells; Nanotube Dimension; Osteoclasts; Osteoporosis; Titania Nanotube
类别
资金
- National Natural Science Foundation of China [81271934]
- Specialized Research Fund for the Health Industry of the Ministry of Health [201002018]
- Fundamental Research Funds for the Central Universities [2013YGYL017]
Implants that can inhibit osteoclastogenesis and enhance osteogenesis are desirable for osteoporosis patients. In this study, titania nanotube (Ti-NT) materials, having nanotube diameters of 30, 80, and 120 nm, were produced separately by anodization at 10, 40, and 60 V, respectively. The introduction of Ti-NTs to titanium substrates significantly reduced the formation and activity of osteoclasts on samples. With the enlargement of the nanotube diameter, the osteoclasts number, tartrate-resistant acid phosphatase staining and activity, and related gene expressions of osteoclasts were further reduced. Osteogenic ability was enhanced by increasing the nanotube diameter. Thus, larger-diameter nanotube implants, such as NT60, were better able to inhibit bone absorption and enhance bone formation to prevent implant loss and failure, especially for osteoporosis patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据