期刊
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
卷 54, 期 1, 页码 1-16出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2011.565523
关键词
Reactive oxygen species; vascular endothelial growth factor; angiogenesis; diabetic retinopathy; lipoxins; resolvins; cytokines; inflammation
资金
- Department of Biotechnology, New Delhi, India
Diabetic retinopathy is a common condition that occurs in patients with diabetes with long-standing hyperglycemia that is characterized by inappropriate angiogenesis. This pathological angiogenesis could be a sort of physiological proliferative response to injury by the endothelium. Recent studies suggested that reactive oxygen species (ROS) play a significant role in this angiogenesis. Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor that plays a significant role in diabetic retinopathy. The interaction between VEGF and ROS, and theirs in turn with pro- and anti-inflammatory cytokines and anti-inflammatory bioactive lipid molecules such as lipoxins, resolvins, protectins, and maresins is particularly relevant to understand the pathophysiology of diabetic retinopathy and develop future therapeutic interventions.
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