期刊
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
卷 20, 期 2, 页码 129-139出版社
BEGELL HOUSE INC
DOI: 10.1615/CritRevEukarGeneExpr.v20.i2.30
关键词
Hedgehog signaling; hematopoiesis; hematopoietic stem cells
资金
- National Institutes of Health [R01CA127574, P01CA15396]
- Gabrielle's Angel Foundation for Cancer Research
- Sidney Kimmel Foundation for Cancer Research
- Multiple Myeloma Research Foundation
- Leukemia and Lymphoma Society
- NATIONAL CANCER INSTITUTE [P01CA015396, R01CA127574] Funding Source: NIH RePORTER
The Hedgehog signaling pathway is highly conserved and plays an essential role in the embryonic development of a wide variety of organs. In adult tissues, such as the central nervous system, it may also be required for homeostasis and repair following injury. The role of Hedgehog signaling in regulating hematopoiesis is not entirely clear. Evidence has shown that Hedgehog signaling is required for both primitive hematopoiesis in the developing embryo, as well as for definitive hematopoiesis in the adult. However, several studies also suggest that Hedgehog pathway activity is completely dispensable in postnatal hematopoiesis. In this review, we discuss the current understanding of Hedgehog signaling in vertebrate hematopoiesis, as well as the contradictory findings that have been reported.
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