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Tissue inhibitor of metalloproteinases-4 suppresses vascular smooth muscle cell migration and induces cell apoptosis
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TIMP-1 inhibits microvascular endothelial cell migration by MMP-dependent and MMP-independent mechanisms
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The hemopexin domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) is not required for its activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen
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The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential
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Deregulation of the IGF axis in cancer: epidemiological evidence and potential therapeutic interventions
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M Kioi et al.
ONCOGENE (2003)
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Loss of collagenase-2 confers increased skin tumor susceptibility to male mice
M Balbín et al.
NATURE GENETICS (2003)
Drosophila TIMP is a potent inhibitor of MMPs and TACE:: Similarities in structure and function to TIMP-3
S Wei et al.
BIOCHEMISTRY (2003)
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CA Fernández et al.
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Activated integrin αvβ3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells
M Rolli et al.
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I Stamenkovic
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Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors
M Ahonen et al.
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A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity
CA London et al.
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Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice
EEJM Creemers et al.
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Inhibition of TIMP1 enhances angiogenesis in vivo and cell migration in vitro
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The favorable prognostic impact of tissue inhibitor of matrix metalloproteinases-1 protein overexpression in breast cancer cells
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L Troeberg et al.
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WC Hahn et al.
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WW Spurbeck et al.
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H Yoshiji et al.
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OP Rahkonen et al.
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Both tissue inhibitors of metalloproteinases-1 (TIMP-1) and TIMP-2 activate Ras but through different pathways
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
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M Ahonen et al.
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DA Young et al.
BIOCHEMICAL JOURNAL (2002)
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Tissue inhibitor of metalloproteinase-3 induces a Fas-associated death domain-dependent type II apoptotic pathway
M Bond et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Expression of sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
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PATHOLOGY INTERNATIONAL (2002)
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SCIENCE (2002)
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FR Murphy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Localization and expression of tissue inhibitor of metalloproteinase-1 in human urothelial cancer
A Yano et al.
JOURNAL OF UROLOGY (2002)
Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells
R Ala-Aho et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
New functions for the matrix metalloproteinases in cancer progression
M Egeblad et al.
NATURE REVIEWS CANCER (2002)
TIMP-1 overexpression in pancreatic cancer attenuates tumor growth, decreases implantation and metastasis, and inhibits angiogenesis
M Bloomston et al.
JOURNAL OF SURGICAL RESEARCH (2002)
Adenovirus mediated gene delivery of tissue inhibitor of metalloproteinases-3 induces death in retinal pigment epithelial cells
MA Majid et al.
BRITISH JOURNAL OF OPHTHALMOLOGY (2002)
Correlation of tissue inhibitor of metalloproteinase-2 with proliferative activity and patients' survival in breast cancer
L Nakopoulou et al.
MODERN PATHOLOGY (2002)
Tissue inhibitor of metalloproteinases 1 is an autocrine and paracrine survival factor, with additional immune-regulatory functions, expressed by Hodgkin/Reed-Sternberg cells
E Oelmann et al.
BLOOD (2002)
Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix
KM Yeow et al.
MATRIX BIOLOGY (2002)
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F Mannello et al.
APOPTOSIS (2001)
Rac affects invasion of human renal cell carcinomas by up-regulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression
R Engers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Adenoviral delivery of TIMP1 or TIMP2 can modify the invasive behavior of pancreatic cancer and can have a significant antitumor effect in vivo
AS Rigg et al.
CANCER GENE THERAPY (2001)
MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function
AT Ho et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Differential growth regulation in human melanoma cell lines by TIMP-1 and TIMP-2
T Hoashi et al.
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Accelerated apoptosis in the Timp-3-deficient mammary gland
JE Fata et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Phenotypic alterations in Caki-1 Cells as a consequence of TIMP-1 over-expression
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Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial
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BRITISH JOURNAL OF CANCER (2001)
Cg-TIMP, an inducible tissue inhibitor of metalloproteinase from the Pacific oyster Crassostrea gigas with a potential role in wound healing and defense mechanisms
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FEBS LETTERS (2001)
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NATURE (2001)
TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)
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Tissue inhibitor of metalloproteinase-1 alters the tumorigenicity of Burkitt's lymphoma via divergent effects on tumor growth and angiogenesis
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AdTIMP-2 inhibits tumor growth, angiogenesis, and metastasis, and prolongs survival in mice
H Li et al.
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C Gruss et al.
CURRENT OPINION IN ONCOLOGY (2001)
Development of matrix metalloproteinase inhibitors in cancer therapy
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Tissue inhibitor of metalloproteinases-2 (TIMP-2) suppresses TKR-growth factor signaling independent of metalloproteinase inhibition
SE Hoegy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Inhibition of liver metastasis from orthotopically implanted colon cancer in nude mice by transfection of the TIMP-1 gene into KM12SM cells
K Yamauchi et al.
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Systemic gene therapy with anti-angiogenic factors inhibits spontaneous breast tumor growth and metastasis in MMTVneu transgenic mice
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ADAMTS: a novel family of extracellular matrix proteases
BL Tang
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I Stamenkovic
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Oncogenes and angiogenesis: Signaling three-dimensional tumor growth
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FEBS LETTERS (2000)
TIMP-3 binds to sulfated glycosaminoglycans of the extracellular matrix
WH Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
TIMP-2 is required for efficient activation of proMMP-2 in vivo
ZP Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3
GA McQuibban et al.
SCIENCE (2000)
The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3
A Amour et al.
FEBS LETTERS (2000)
Tissue inhibitors of metalloproteinases: evolution, structure and function
K Brew et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY (2000)
The ADAM gene family - surface proteins with adhesion and protease activity
P Primakoff et al.
TRENDS IN GENETICS (2000)
Inhibition of late vein graft neointima formation in human and porcine models by adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-3
SJ George et al.
CIRCULATION (2000)
Cellular turnover and extracellular matrix remodeling in female reproductive tissues: functions of metalloproteinases and their inhibitors
JE Fata et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2000)
Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer
Y Yonemura et al.
CLINICAL & EXPERIMENTAL METASTASIS (2000)
Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice
L Roten et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2000)
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