期刊
CRITICAL REVIEWS IN BIOTECHNOLOGY
卷 34, 期 4, 页码 328-337出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/07388551.2013.794413
关键词
Bioactive molecules; carriers; cross-link agent; drug delivery; supramolecular structures
资金
- Foundation for Science and Technology (Portugal) [SFRH/BD/62665/2009]
- FCT - Fundacao para a Ciencia e a Tecnologia [PEst-C/CTM/UI0264/2011]
- Fundação para a Ciência e a Tecnologia [PEst-C/CTM/UI0264/2011, SFRH/BD/62665/2009] Funding Source: FCT
Optimal wound dressings should be capable of mechanical wound protection and also facilitate the healing process via maintenance of suitable environmental conditions and the controlled delivery of bioactive molecules. Hydrogels present suitable properties for wound-dressing applications such as good biocompatibility, together with a high water content, the latter of which is important for the maintenance of a moist environment and ready removal from the wound with a minimal level of associated pain. However, their properties as drug delivery systems can be improved by the use of cyclodextrins as cross-linking agents. Cyclodextrins have been extensively used as carriers on food, textile, cosmetic and, most especially, in the pharmaceutical industry in view of their powerful complexation abilities and biocompatibilities, together with further desirable characteristics. The conjugation of cyclodextrins with hydrogels may allow the achievement of an optimal wound-dressing material, because the hydrogel component will maintain the moist environment required for the healing process, and the cyclodextrin moiety has the ability to protect and modulate the release of bioactive molecules. Therefore, this review aims to gather information regarding cyclodextrin-based hydrogels for possible wound-dressing applications.
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