期刊
CRITICAL REVIEWS IN BIOTECHNOLOGY
卷 35, 期 1, 页码 15-28出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/07388551.2013.795516
关键词
Biocatalysis; cross-linked enzyme aggregates; enzyme immobilization; improved strategies; process optimization
资金
- National Natural Science Foundation of China (NSFC) [21072041]
- Foundation of Tianjin Key Laboratory of Industrial Microbiology (Tianjin University of Science and Technology), P. R. China [2012IM004]
- Foundation of Hebei University of Science and technology for Distinguished Young Scientists
Cross-linked enzyme aggregate (CLEA) technology has been regarded as an effective carrier-free immobilization method. This method is very attractive due to its simplicity and robustness, as well as for the possibility of using the crude enzyme extract and the opportunity to co-immobilize multiple different enzymes. The resulting CLEAs generally exhibit high catalyst productivities, improved storage and operational stability and are easy to recycle. Nowadays, although the technology has been applied to various enzymes, some undesirable properties have limited its further application. To overcome these limitations, novel strategies have been developing in recent years. This mini-review focuses on process optimization, new improved strategies and the latest advances on CLEAs technology.
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