期刊
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 49, 期 1, 页码 1-15出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10409238.2013.838205
关键词
Chromatin; histones; hydroxylation; hypoxia response element; mediator; p300; RNA polymerase II
资金
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1627615] Funding Source: National Science Foundation
- NCI NIH HHS [R01 CA117907] Funding Source: Medline
- NIGMS NIH HHS [T32 GM142607, T32 GM008759] Funding Source: Medline
The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.
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