期刊
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 47, 期 6, 页码 493-501出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10409238.2012.714350
关键词
RNA; RNA editing; ADAR; inosine; miRNA; siRNA; adenosine deaminase; dsRNA
资金
- National Institutes of Health [GM040536, HL099342]
- Ellison Medical Foundation [AG-55-2281-09]
- Commonwealth Universal Research Enhancement Program, Pennsylvania Department of Health
Adenosine deaminase acting on RNA (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) substrates. Inosine pairs preferentially with cytidine, as opposed to uridine; therefore, ADAR editing alters the sequence and base pairing properties of both protein-coding and non-coding RNA. Editing can directly alter the sequence of protein-coding transcripts and modify splicing, or affect a variety of non-coding targets, including microRNA, small interfering RNA, viral transcripts, and repeat elements such as Alu and LINE. Such editing has a wide range of physiological effects, including modification of targets in the brain and in disease states.
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