期刊
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 44, 期 2-3, 页码 117-141出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409230902858785
关键词
Gene regulation; chromatin; genome-wide; pre-initiation complex; histone modification; transcription cycle; noncoding RNA
资金
- NIH/NIEHS [ES013768]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES013768] Funding Source: NIH RePORTER
Regulation of eukaryotic gene expression is far more complex than one might have imagined 30 years ago. However, progress towards understanding gene regulatory mechanisms has been rapid and comprehensive, which has made the integration of detailed observations into broadly connected concepts a challenge. This review attempts to integrate the following concepts: (1) a well-defined organization of nucleosomes and modification states at most genes; (2) regulatory networks of sequence-specific transcription factors; (3) chromatin remodeling coupled to promoter assembly of the general transcription factors and RNA polymerase 11; and (4) phosphorylation states of RNA polymerase 11 coupled to chromatin modification states during transcription. The wealth of new insights arising from the tools of biochemistry, genomics, cell biology, and genetics is providing a remarkable view into the mechanics of gene regulation.
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