期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 15, 期 3, 页码 2060-2066出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2015.9539
关键词
Reduced Graphene Oxide; Functionalized Graphene Oxide; Dodecyl Amine; Cell Viability
类别
资金
- Mid-career Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2011-0028752]
- Center for Green Airport Pavement Technology (CGAPT) of Chung-Ang University
The viability of A549 cells, a human lung carcinoma epithelial cell line, was evaluated after exposure to graphene oxide (GO) and its derivatives (dodecylamine GO (DA-GO), reduced GO (rGO), and sodium dodecyl sulfate rGO (SDS-rGO)). A decrease in the relative amounts of C-OH bonds and an increase in the number of C-C and C-N bonds in the C is spectra indicated that the reduction of GO to rGO and the surface functionalization of GO has taken place. The appearance of amine stretching bands, out-of-plane C-H stretching vibrations, and S=O stretching bands in the infrared spectra indicated the formation of DA-GO, rGO, and SDS-rGO, respectively. Low concentrations (3-25 mu g/mL) of GO, rGO, and SDS-rGO were found to be mildly toxic, whereas DA-GO exhibited severe dose-dependent toxicity over the same concentration range. High concentrations (50-400 mu g/mL) of GO and all its derivatives resulted in severe toxicity to the A549 cells. It is believed that surface functionality strongly affects the viability of A549 cells.
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