期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 15, 期 8, 页码 5610-5616出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2015.10465
关键词
Secretory Leukocyte Protease Inhibitor; 660 nm Red LED; Macrophage; Inflammation
类别
资金
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [R13-2008-010-01001-0]
- National Research Foundation of Korea [R13-2008-010-01001-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
SLPI acts as a modulator of the innate immune responses of macrophages, neutrophils and odonto-blasts, and LPS-inducible anti-inflammatory cytokine to suppress the production of pro-inflammatory products by macrophages. Many studies have revealed the effects of light emitting diodes (LEDs) on the tissue repair and inflammatory responses. Although the anti-inflammatory mechanisms of irradiation with LEDs in gingival fibroblasts are known, the effects of 660 nm red LEDs on the inflammation remain unclear. Moreover, there is no report regarding the molecular mechanism for the relationship between SLPI and biological effects of LEDs. The effects of 660 nm red LEDs on inflammation with SLPI were investigated by examining the effects of 660 nm LED on the SLPI expression of RAW264.7 cells after LPS stimulation. This paper reports that the 660 nm red LED induced SLPI expression or reduced the LPS response, and inhibited NF-kappa B activation directly, leading to the suppression of pro-inflammatory cytokines, such as TNF-alpha and IL-1 beta, suggesting that it might be a useful wavelength LED for inflammation therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据