期刊
CRITICAL CARE MEDICINE
卷 38, 期 -, 页码 S555-S558出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CCM.0b013e3181f20d5b
关键词
mechanical ventilation; acute respiratory failure; acute lung injury; acute respiratory distress syndrome; continuos positive airway pressure; extracorporeal membrane oxygenation; extracorporeal carbon dioxide removal; molecular mechanisms of injury; prevention
Mechanical ventilation is a lifesaving treatment delivered to patients with a wide spectrum of medical and surgical diseases. However, significant limitations of the clinical application of mechanical ventilation in current practice have emerged, prompting the definition of novel therapeutic perspectives, especially concerning the prevention and treatment of acute respiratory failure. In the past few decades, there has been a consistent scientific and technologic effort to develop alternative strategies to avoid the need for mechanical ventilation. In particular, several studies have explored the feasibility and efficacy of extracorporeal oxygenation and carbon dioxide removal. Furthermore, promising results on the prevention of the occurrence of severe acute respiratory failure have been provided by clinical studies on the noninvasive application of continuous positive airway pressure as well as by experimental investigations in basic science. Therefore, further development in this direction will occur only with a permanent integration and exchange of knowledge among industry, clinicians, and scientific investigators. (Crit Care Med 2010; 38[Suppl.]:S555-S558)
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