期刊
CRITICAL CARE MEDICINE
卷 37, 期 2, 页码 441-447出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CCM.0b013e318194ac44
关键词
septic shock; myocardial dysfunction; echocardiography
Objective: Whether cardiac ventricles can acutely dilate during septic myocardial dysfunction. Design: A prospective echocardiographic study was performed to assess changes of left ventricular dimensions over time in patients with septic shock. Settings: A 20-bed surgical intensive care unit of Pitie-Salpetriere university hospital in Paris. Patients: Forty-five patients were studied over the first 10 days of septic shock. Interventions: None. Measurements and Main Results. Left ventricular end-diastolic area (LVEDA), fractional area change (FAC), velocity time integral of the aortic flow, echocardiographic indices of left ventricular relaxation, and cardiac troponin I (cTnI) were measured at day 1, 2, 3, 4, 7, and 10. Three groups were defined: 29 patients without increased cTnl and cardiac impairment (group 1), eight patients with increased cTnl and left systolic ventricular dysfunction (group 2), and eight patients with increased cTnI and isolated impairment of left ventricular relaxation (group 3). At day 1, LVEDA was significantly higher in group 2 (13 +/- 3 cm/m(2), p < 0.05) compared with groups 1 (10 +/- 2 cm/m(2)) and 3 (11 +/- 2 cm/m(2)). LVEDA did not change in groups 1 and 3. In group 2, LVEDA and FAC returned within 10 days to values observed in groups 1 and 2. A significant correlation was found between aortic velocity time integral and LVDEA (r =.78, p = 0.022) and FAC (r =.89, p = 0.003) only in group 2. Conclusions: Acute and reversible left ventricular dilation accompanies septic shock-induced systolic left ventricular dysfunction. When septic myocardial abnormalities are limited to reversible impairment of left ventricular relaxation, left ventricular dimensions remain unchanged. (Crit Care Med 2009; 37:441-447)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据