4.6 Article

Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock

期刊

CRITICAL CARE MEDICINE
卷 36, 期 4, 页码 1297-1303

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CCM.0b013e318169245a

关键词

serum neutrophil gelatinase-associated lipocalin; biomarker; acute kidney injury; septic shock

资金

  1. NIDDK NIH HHS [R21 DK070163, R21 DK070163-01] Funding Source: Medline
  2. NIGMS NIH HHS [K08 GM077432, R01 GM064619, K08 GM077432-04, R01 GM064619-06] Funding Source: Medline

向作者/读者索取更多资源

Objective: To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury in critically ill children with septic shock. Design: Observational cohort study. Setting. Fifteen North American pediatric intensive care units (PICUs). Patients: A total of 143 critically ill children with systemic inflammatory response syndrome (SIRS) or septic shock and 25 healthy controls. Interventions: None. Measurements and Main Results: Serum NGAL was measured (luring the first 24 hrs of admission to the PICU. Acute kidney injury was defined as a blood urea nitrogen concentration >100 mg/dL, serum creatinine >2 mg/dL in the absence of preexisting renal disease, or the need for dialysis. There was a significant difference in serum NGAL between healthy children (median 80 ng/mL, interquartile ratio [IQR] 55.5-85.5 ng/mL), critically ill children with SIRS (median 107.5 ng/mL, IQR 89-178.5 ng/mL), and critically ill children with septic shock (median 302 ng/mL, IQR 151-570 ng/mL; p <.001). Acute kidney injury developed in 22 of 143 (15.4%) critically ill children. Serum NGAL was significantly increased in critically ill children with acute kidney injury (median 355 ng/mL, IQR 166-1322 ng/mL) compared with those without acute kidney injury (median 186 ng/mL, IQR 98-365 ng/mL; p =.009). Conclusions: Serum NGAL is a highly sensitive but nonspecific predictor of acute kidney injury in critically ill children with septic shock. Further validation of serum NGAL as a biomarker of acute kidney injury in this population is warranted.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据