期刊
CORTEX
卷 46, 期 7, 页码 869-879出版社
ELSEVIER MASSON, CORPORATION OFFICE
DOI: 10.1016/j.cortex.2009.09.002
关键词
Cerebellum; Adults; Cognition; Cognitive-affective syndrome; SPECT
资金
- Fund for Scientific Research - Flanders (F.W.O. - Vlaanderen) [G.0209.05]
- Onderzoeksraad (OZR-VUB)
- Nationale Vereniging tot Steun aan Gehandicapte Personen (NVSG-ANAH)
- Stichting Integratie Gehandicapten (SIG)
- Deloitte Belgium
The traditional view on cerebellar functioning has recently been challenged by results from neuroanatomical, neuroimaging and clinical studies. In this contribution, eighteen patients with primary cerebellar lesions (vascular: n = 13; neoplastic: n = 5) were systematically investigated by means of an extensive neuropsychological test battery. Fifteen patients (83%) presented with a broad variety of cognitive and linguistic deficits following cerebellar damage. Disturbances of attention (72%), executive functioning (50%) and memory (50%) were most commonly found. Analyses of our results tend to support the hypothesis of a lateralization of cognitive modulation within the cerebellum, the right cerebellar hemisphere being associated with logical reasoning and language processing and the left cerebellum mediating right-hemispheric functions including attentional and visuo-spatial skills. In addition, nine patients (50%) presented with frontal-like behavioural and affective alterations. In an attempt to determine the working-mechanism underlying cerebellar-induced cognitive and affective disturbances, all patients were investigated by means of quantified Tc-99m-ethylenecysteine dimer (ECD) single photon emission computerized tomography (SPECT) studies. From a semiological point of view, damage to the cerebellum can cause a broad spectrum of clinically significant cognitive and affective disturbances. From a pathophysiological point of view, quantified SPECT data, reflecting the phenomenon of cerebello-cerebral diaschisis, support the functional impact of the cerebellar lesion on cortical functioning through disruption of cerebello-cerebral connections. (C) 2009 Elsevier Srl. All rights reserved.
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