期刊
CORNEA
卷 32, 期 6, 页码 729-736出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ICO.0b013e31827b14c7
关键词
cornea transplantation; cornea thickness; graft survival
资金
- National Eye Institute, National Institutes of Health
- Department of Health and Human Services [EY12728, EY12358]
- Eye Bank Association of America
- Bausch Lomb Inc
- Tissue Banks International
- Vision Share Inc
- San Diego Eye Bank
- Cornea Society
- Katena Products Inc
- ViroMed Laboratories Inc
- Midwest Eye-Bank(Michigan Eye-Bank)
- Midwest Eye-Bank(Illinois Eye-Bank)
- Konan Medical Corp
- Eye Bank for Sight Restoration
- SightLife
- Sight Society of Northeastern New York (Lions Eye Bank of Albany)
- Lions Eye Bank of Oregon
Purpose: To assess corneal thickness (CT) and correlation with graft outcome after penetrating keratoplasty in the Cornea Donor Study. Methods: A total of 887 subjects with a corneal transplant for a moderate-risk condition (principally Fuchs dystrophy or pseudophakic corneal edema) had postoperative CT measurements throughout a 5-year follow-up time. Relationships between baseline (recipient, donor, and operative) factors and CT were explored. Proportional hazards models were used to assess the association between CT and graft failure. Relationship between CT and cell density was assessed with a longitudinal repeated measures model and Spearman correlation estimates. Results: Higher longitudinal CT measurements were associated with the following: diagnosis of pseudophakic or aphakic corneal edema (P < 0.001), intraocular pressure > 25 mm Hg during the first postoperative month (P = 0.003), white (non-Hispanic) donor race (P = 0.002), and respiratory causes of donor death (P < 0.001). Among those without graft failure within the first postoperative year, the 5-year cumulative incidence (+/- 95% confidence interval) of graft failure was 5% +/- 5% in those with a 1-year CT <= 500 mu m, 5% +/- 3% for CT 501 to 550 mu m, 7% +/- 4% for CT 551 to 600 mu m, and 20% +/- 11% for CT > 600 mu m. In a multivariate analysis, both 1-year CT and cell density were associated with subsequent graft failure (P = 0.002 and 0.009). CT increase was modestly associated with endothelial cell loss during follow-up (r = -0.29). Conclusions: During the first 5 years after penetrating keratoplasty, CT can serve as a predictor of graft survival. However, CT is not a substitute for cell density measurement because both measures were independently predictive of graft failure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据