期刊
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
卷 10, 期 -, 页码 50-53出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/15412555.2013.765838
关键词
alpha-1-antitrypsin; deficiency; emphysema
AATD is a European genetic condition that has disseminated along human migration routes. The discovery, function, phenotyping methodologies and biochemical mechanisms have been led by several European countries. The variable availability of augmentation therapy has permitted a better understanding of the natural history and the ability to deliver controlled clinical trials. The establishment of a worldwide registry remains central to the future of understanding and managing AATD.
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