期刊
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
卷 9, 期 4, 页码 352-358出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/15412555.2012.669433
关键词
Alpha 1-Antitrypsin Deficiency; Spirometry; Respiratory Care; Chronic Obstructive Pulmonary Disease; Pulmonary Function Test
资金
- Alpha-1 Foundation
- NIH
- Astra Zeneca
- Talecris Biotherapeutics
- Baxter Healthcare
- Grifols, Inc.
- CSL-Behring, Inc.
- Baxter Healthcare CSL-Behring, Inc.
- Grifols
- Kamada
- CSL Behring
- Dey
- Alpha-1 Association
- Centocor
- Forest
- Novartis
- Pfizer
- Talecris
- Baxter
- Talecris Biotherapeutics (Grifols)
Introduction: Alpha-1 antitrypsin deficiency (AATD) is a genetic disease that may be manifested by chronic obstructive pulmonary disease. Despite professional society guidelines that recommend broad testing of at-risk individuals, fewer than 10% of affected individuals have been identified. The goals of this study were to estimate the frequency of abnormal AAT genotypes among patients found to have fixed airflow obstruction and to assess the feasibility of having Pulmonary Function Laboratory personnel administer the study. Methods: Nineteen medical centers in the United States participated in the study. Eligible patients (> GOLD II, FEV1/FVC ratio < 0.7, with post-bronchodilator FEV1<80% predicted) were offered testing for AATD by the Pulmonary Function Laboratory personnel at the time of pulmonary function testing. Results: A total of 3,457 patients were tested, of whom 3152 were eligible. Deficient patients (ZZ, SZ) constituted 0.63% of subjects, while 10.88% were carriers (MS, MZ). Neither demographic (except African-American race) nor post-bronchodilator pulmonary function variables (FEV1, FVC, FEV1/FVC ratio, TLC, and FEV1/FVC) allowed us to predict AAT heterozygote or deficiency status. Conclusions: The prevalence of AATD among patients undergoing pulmonary function tests with fixed airflow obstruction was 0.63%. Pulmonary Function Laboratory personnel effectively conducted the study.
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