期刊
COORDINATION CHEMISTRY REVIEWS
卷 256, 期 19-20, 页码 2381-2396出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2012.03.015
关键词
Amyloid; Peptide; Metal ions; Copper; Zinc; Aggregation; Bioinorganic chemistry; Neurodegeneration; Methods; Physico-chemical techniques
资金
- Agence Nationale de la Recherche [NT09-488591, 05-JCJC-0010-01]
- Region Midi-Pyrenees [APRTCN09004783]
This article provides a review about the most common techniques used to study the interaction of metal ions with amyloidogenic peptides. It is addressed to researchers, who want to know what kind of techniques exists, the information which can be obtained, their advantages, limits and the demands concerning sample preparation etc. It is not addressed to specialists of these techniques as the physical principles of the techniques are nor given. First, a general overview is given about sample preparation and treatment, with focus on the metal ions Zn(II), Cu(I/II) and Fe(II/III) and the peptides amyloid-beta (but also a-synuclein, prion etc.). Then the methods NMR, EPR, electrochemistry, optical spectroscopy, isothermal titration calorimetry, FTIR, X-ray absorption and mass spectrometry are treated. (C) 2012 Elsevier B.V. All rights reserved.
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