期刊
COORDINATION CHEMISTRY REVIEWS
卷 256, 期 19-20, 页码 2219-2224出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2011.12.008
关键词
Zinc; Alzheimer's disease; Parkinson disease; Priori; Amyloid-beta
资金
- Estonian Ministry of Education and Research [SF0140055s08]
- Estonian Science Foundation [8811]
Major neurodegenerative disorders, including Alzheimer's and Parkinsons's disease and prion related pathologies are associated with protein misfolding and aggregation. Proteins involved in all the listed diseases are able to form complexes with metal ions and there is a dyshomeostasis and miscompartmentalization of the transition metals in the brain during these diseases. Therefore, it is important to understand the interactions between the key proteins of the neurodegenerative diseases and the transition metal ions and its consequences. We give a review on the coordination chemistry of zinc ions to A. APP, alpha-synuclein and PrP. (C) 2011 Elsevier B.V. All rights reserved.
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