期刊
COORDINATION CHEMISTRY REVIEWS
卷 255, 期 9-10, 页码 1129-1144出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2010.12.003
关键词
Molybdenum cofactor; Molybdopterin; Precursor Z; Molybdopterin guanine dinucleotide cofactor; Urothione; Dithiolene group
资金
- Deutsche Forschungsgemeinschaft
- NIH
The biosynthesis of the molybdenum cofactor in bacteria is described with a detailed analysis of each individual reaction leading to the formation of stable intermediates during the synthesis of molybdopterin from GTP. As a starting point, the discovery of molybdopterin and the elucidation of its structure through the study of stable degradation products are described. Subsequent to molybdopterin synthesis, the molybdenum atom is added to the molybdopterin dithiolene group to form the molybdenum cofactor. This cofactor is either inserted directly into specific molybdoenzymes or is further modified by the addition of nucleotides to molybdopterin phosphate group or the replacement of ligands at the molybdenum center. (C) 2010 Elsevier B.V. All rights reserved.
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