期刊
COORDINATION CHEMISTRY REVIEWS
卷 255, 期 9-10, 页码 1039-1054出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2010.11.027
关键词
Molybdoenzymes; Structural-functional modeling; Oxygen atom transfer; Mnt; Sulfite oxidase; Aldehyde ferredoxin oxidoreductase; Formate dehydrogenase; Acetylene hydratase; Polysulfide reductase; Nitrate reductase
资金
- Department of Science and Technology, New Delhi
Chemical approaches toward the bioinorganic chemistry of molybdenum and tungsten enzymes had been either biomimetic (structural modeling) or bioinspired (functional modeling). Among the dithiolene type of ligands, bdt (1,2-benzene dithiolate) and related aromatic molecules as model ene-dithiolene ligands were used to react with pre-designed molybdenum complexes in organic solvents. Whereas in the alternative approach mnt (maleonitrile dithiolate) is used to mimic the ligand backbone of the central atom in the active sites of these enzymes using molybdate or tungstate as the metal source in water. Structural-functional models are known for some selected enzymes, namely, sulfite oxidase, aldehyde ferredoxin oxidoreductase, tungsten formate dehydrogenase, acetylene hydratase, polysulfide reductase and dissimilatory nitrate reductase. The protocols and methodologies adopted to achieve these model systems compared with various other model systems described in this review give testimony to chemist's ability, through chemical manipulations, to achieve the model systems which may potentially serve as structural-functional mimics of natural enzyme systems. (C) 2010 Elsevier B.V. All rights reserved.
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