期刊
COORDINATION CHEMISTRY REVIEWS
卷 252, 期 21-22, 页码 2239-2277出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2008.01.016
关键词
Heteronuclear NMR spectroscopy; Quadrupolar nuclei; Biological systems; Bioinorganic chemistry; Medicinal inorganic chemistry; Metallopharmaceuticals
资金
- EC (Marie Curie Fellowship)
- Korber Foundation
There is a wide range of potential applications of inorganic compounds, and metal coordination complexes in particular, in medicine but progress is hampered by a lack of methods to study their speciation. The biological activity of metal complexes is determined by the metal itself, its oxidation state, the types and number of coordinated ligands and their strength of binding, the geometry of the complex, redox potential and ligand exchange rates. For organic drugs a variety of readily observed spin I = 1/2 nuclei can be used (H-1, C-13, N-15, F-19, P-31), but only a few metals fall into this category. Most are quadrupolar nuclei giving rise to broad lines with low detection sensitivity (for biological systems). However we show that, in some cases, heteronuclear NMR studies can provide new insights into the biological and medicinal chemistry of a range of elements and these data will stimulate further advances in this area. (C) 2008 Elsevier B.V. All rights reserved.
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