期刊
CONTRAST MEDIA & MOLECULAR IMAGING
卷 6, 期 5, 页码 332-345出版社
WILEY-HINDAWI
DOI: 10.1002/cmmi.443
关键词
photoacoustic tomography; photoacoustic microscopy; photoacoustic computed tomography; photoacoustic endoscopy; multiscale imaging; optical absorption contrast
资金
- National Institutes of Health [R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, 5P60 DK02057933]
Optical microscopy has been contributing to the development of life science for more than three centuries. However, due to strong optical scattering in tissue, its in vivo imaging ability has been restricted to studies at superficial depths. Advances in photoacoustic tomography (PAT) now allow multiscale imaging at depths from sub-millimeter to several centimeters, with spatial resolutions from sub-micrometer to sub-millimeter. Because of this high scalability and its unique optical absorption contrast, PAT is capable of performing anatomical, functional, molecular and fluid-dynamic imaging at various system levels, and is playing an increasingly important role in fundamental biological research and clinical practice. This review discusses recent technical progress in PAT and presents corresponding applications. It ends with a discussion of several prospects and their technical challenges. Copyright (C) 2011 John Wiley & Sons, Ltd.
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