期刊
CONTRAST MEDIA & MOLECULAR IMAGING
卷 6, 期 6, 页码 482-491出版社
WILEY-BLACKWELL
DOI: 10.1002/cmmi.448
关键词
gadolinium complexes; contrast agents; relaxivity; magnetic resonance imaging; polysaccharides
资金
- European Union [MEST-CT-2004-7442]
- Fonds de la Recherche Scientifique
- ARC, French Community of Belgium [05/10-335]
- European Community
- European Regional Development Fund
- Walloon Region (CMMI)
- COST Action [D38]
- EMIL
Reaction of DOTANCSA [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono(p-isothiocyanatoanilide)] with O-(aminopropyl)inulin (degree of polymerization 25) provided a chelate that formed a kinetically extremely stable Gd3+ complex. No transmetalation was observed with Zn2+. The conjugate has a relaxivity of 21.7s(-1) m m-1 at 20MHz and 37 degrees C, and each molecule of the inulin carries on average 35 Gd3+ ions. The parameters governing the relaxivity of this material and of a low-molecular-weight model compound prepared by conjugation of DOTANCSA and propylamine were evaluated by investigation of their water 1H longitudinal relaxation rate enhancements at different magnetic fields (NMRD) and by studying variable temperature 17O NMR data. The high relaxivity of the inulin conjugate can be ascribed to the efficient slowing down of the molecular tumbling by this carrier. The rotational correlation time at 37 degrees C of this material is 1460ps, whereas that of the model compound is 84ps. Furthermore, both complexes do not interact significantly with human serum albumin, as shown by their NMRD profiles, and do not undergo transmetallation by zinc ions. The inulin conjugate thus has potential for application as a contrast agent for MRI, particularly as a blood pool agent. Copyright (C) 2011 John Wiley & Sons, Ltd.
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