期刊
CONTRACEPTION
卷 84, 期 4, 页码 357-362出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.contraception.2011.02.001
关键词
Oral contraceptive; Bone mineral density; Vertebral deformity; Fracture; Population
资金
- National Health and Medical Research Council of Australia
- Arthritis Foundation of Australia
- Tasmanian Community
- Masonic Centenary Medical Research Foundation
- Royal Hobart Hospital Research Foundation
- University of Tasmania
Background: The associations between oral contraceptive (OC) use, bone mineral density (BMD) and the risk of fractures remain controversial. Study Design: A cross-sectional study of 491 women aged 50-80 years was performed. We assessed OC use and fractures by questionnaire, and BMD and vertebral deformity by dual-energy x-ray absorptiometry. Results: Ever use of OC was associated with significantly higher BMD at the total body (6%, p<.001) and spine (4%; p=.05) (but not hip) after adjustment for confounders. There was also a significant association between duration of OC use and total body and spine BMD. Use of OCs for 5-10 years was associated with reduced vertebral deformity (adjusted odds ratio 0.46, 95% confidence interval 0.22-0.94). Conclusions: Oral contraceptive use and duration were associated with higher total body and spine BMD and a consistent reduction in vertebral deformities, although most associations did not reach significance. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved.
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