期刊
CONTRACEPTION
卷 79, 期 2, 页码 134-138出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.contraception.2008.09.007
关键词
Frameless intrauterine system; Levonorgestrel (LNG); Contraception; Menstrual blood loss; Heavy menstrual bleeding
Background: This study was conducted to report on a menstrual blood loss (MBL) study and iron stores in women with and without heavy menstrual bleeding using the frameless FibroPlant (R) levonorgestrel-releasing intrauterine system (LNG-IUS) for contraception. Study design: An open, prospective, noncomparative MBL study, using FibroPlant (R) releasing 14 mcg of LNG/day for contraception. MBL was assessed by the quantitative alkaline hematin (QAH) technique. Results: The MBL study was conducted in 40 heavy and normally menstruating Brazilian women seeking contraception. MBL was reduced from a mean baseline menstrual volume of 29.7 mL to a mean volume of 1.5 mL after 24 months. while ferritin values increased from a mean value of 31.1 ng/mL (at baseline) to a mean level of 72.5 ng/mL (after 24 months of use). Differences were highly significant (p<.0005). There were no significant differences between those who had normal menstrual bleeding and the heavy bleeders. The heavy bleeders had comparable MBL to the normal bleeders 3 months after insertion, and by 24 months post-insertion, their ferritin levels were comparable to those of the normal bleeders. Amenorrhea occurred in 80% of women out of 40 after 24 months of use. No pregnancies were recorded. Conclusion: The LNG-IUS is effective in reducing MBL in normally menstruating women as well as in women with heavy menstrual bleeding. The authors agree with the recommendations by the UK National Institute for Clinical Effectiveness and the new Finnish guidelines for heavy menstrual bleeding that the LNG-IUS should be positioned as first-line treatment prior to endometrial ablation or hysterectomy. (C) 2009 Elsevier Inc. All rights reserved.
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