期刊
CONTEMPORARY CLINICAL TRIALS
卷 29, 期 2, 页码 241-251出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cct.2007.08.004
关键词
recruitment; randomized controlled trials; irritable bowel syndrome; acupuncture; patient-physician relationship
资金
- NCCIH NIH HHS [R21 AT002564, 1R01 AT01414-01, 1K24 AT004095-01, R01 AT001414, R01 AT001414-01, R21 AT002564-01A1, K24 AT004095, R21 AT002564-01] Funding Source: Medline
- NCRR NIH HHS [M01 RR001032, RR 01032] Funding Source: Medline
A successful clinical trial is dependent on recruitment. Between December 2003 and February 2006, our team successfully enrolled 289 participants in a large, single-center, randomized placebo-controlled trial (RCT) studying the impact of the patient-doctor relationship and acupuncture on irritable bowel syndrome (IBS) patients. This paper reports on the effectiveness of standard recruitment methods such as physician referral, newspaper advertisements, fliers, audio and video media (radio and television commercials) as well as relatively new methods not previously extensively reported on such as internet ads, ads in mass-transit vehicles and movie theater previews. We also report the fraction of cost each method consumed and fraction of recruitment each method generated. Our cost per call from potential participants varied from $3-$103 and cost per enrollment participant varied from $12-$584. Using a novel metric, the efficacy index, we found that physician referrals and flyers were the most effective recruitment method in our trial. Despite some methods being more efficient than others, all methods contributed to the successful recruitment. The iterative use of the efficacy index during a recruitment campaign may be helpful to calibrate and focus on the most effective recruitment methods. (C) 2007 Elsevier Inc. All rights reserved.
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