Synthesis, spectroscopic characterization, antimicrobial activity and crystal structure of [Ag2(C10H10N3O3S)2(C5H5N)3]

Silver complex of 4-Amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide (sulfamethoxazole) (SMX) has been synthesized and characterized by elemental analysis, infrared, UV and NMR spectroscopy. The title compound, [Ag-2(C10H10N3O3S)(2)(C5H5N)(3)] crystallizes in the orthorhombic space group Pna2(1) with lattice parameters a = 17.9527(5), b = 8.6529(3), c= 25.1621(7) angstrom and Z = 4. The structure is solved by direct method and refined to a final R = 0.0567 for 6732 reflections with I >= 2 sigma(I). The results of IR, H-1 NMR and C-13 NMR spectral data suggest the binding of silver atom to the sulfonamide ligand which is in agreement with the crystal structure determination. X-ray analysis revealed that in the title compound, one silver atom is surrounded by three N atoms and one Ag atom leading to a distorted tetrahedral geometry and another silver atom is surrounded by four N atoms and one Ag atom leading to a slightly distorted square pyramid geometry with Ag. -Ag separation distance of 3.026 angstrom. The dihedral angle between phenyl and isoxazole ring is 85.7(4)degrees. In the crystal structure, the molecules are linked via N-H center dot center dot center dot O, C-H center dot center dot center dot O intermolecular and C-H center dot center dot center dot O intramolecular interactions. Silver complex of sulfamethoxazole has been studied by electrical and thermal analysis. Silver sulfamethoxazole presents different antibacterial behavior against Escherichia coli and Staphylococcus aureus strains. (C) 2015 Elsevier B.V. All rights reserved.