期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1098, 期 -, 页码 55-65出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2015.05.034
关键词
Inositol hexakisphosphate; 3d transition metal cations; P-31 NMR of InsP(6) complexes; Solution chemistry of InsP(6)
资金
- Uruguayan organizations PEDE-CIBA (Programa de Desarrollo de las Ciencias Basicas)
- ANII (Agencia Nacional de Investigacion e Innovacion)
- CSIC (Programa de Apoyo a Grupos)
Among myo-inositol phosphates, the most abundant in nature is the myo-inositol hexakisphosphate, InsP(6). Although it is known to be vital to cell functioning, the biochemical research into its metabolism needs chemical and structural analysis of all the protonation, complexation and precipitation processes that it undergoes in the biological media. In view of its high negative charge at physiological level, our group has been leading a thorough research into the InsP(6) chemical and structural behavior in the presence of the alkali and alkaline earth metal ions essential for life. The aim of this article is to extend these studies, dealing with the chemical and structural features of the InsP(6) interaction with biologically relevant 3d transition metal ions (Fe(II), Fe(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)), in a non-interacting medium and under simulated physiological conditions. The metal-complex stability constants were determined by potentiometry, showing under ligand-excess conditions the formation of mononuclear species in different protonation states. Under metal ion excess, polymetallic species were detected for Fe(II), Fe(III), Zn(II) and Cu(II). Additionally, the P-31 NMR and UV vis spectroscopic studies provided interesting structural aspects of the strong metal ion-InsP(6) interaction. (C) 2015 Elsevier B.V. All rights reserved.
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