期刊
JOURNAL OF MOLECULAR NEUROSCIENCE
卷 58, 期 1, 页码 93-101出版社
HUMANA PRESS INC
DOI: 10.1007/s12031-015-0655-x
关键词
Human hair; Heroin abusers; Metabonomics; Ion trap-TOF-MS
资金
- Shenzhen and Hong Kong Innovative Circle Project [JSE201007160003A]
Hair analysis is with the advantage of non-invasive collection and long surveillance window. The present study employed a sensitive and reliable liquid chromatography coupled with ion trap-time of flight mass spectrometry method to study the metabonomic characters in the hair of 58 heroin abusers and 72 non-heroin abusers. Results indicated that certain endogenous metabolites, such as sorbitol and cortisol, were accelerated, and the level of arachidonic acid, glutathione, linoleic acid, and myristic acid was decreased in hair of heroin abusers. The metabonomic study is helpful for further understanding of heroin addiction and clinical diagnosis.
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