期刊
CONNECTIVE TISSUE RESEARCH
卷 50, 期 2, 页码 110-120出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/03008200802471856
关键词
Collagen Fiber; Mast Cell; Type I Collagenase; Degranulation Ratio; Acupoint; Analgesia
资金
- Science Foundation of Shanghai Municipal Commission of Science and Technology [05DZ19745, 06DZ19732, 064319053, 07DZ19722, 07DZ19733]
- National Basic Research Program of China [2005CB523306]
- Shanghai Leading Academic Discipline Project [B112, T0302]
Acupuncture, a traditional Chinese therapeutic technique, has been put into practice for more than 4000 years and widely used for pain management since 1958. However, what is the mechanism underlying the acupuncture for analgesia effects by stimulation of acupoints, what substances receive the original mechanical acupuncture signals from the acupoints, or what transforms these signals into effective biological signals are not well understood. In this work, the role of collagen fibers at acupoints during acupuncture analgesia on rats was investigated. When the structure of the collagen fibers at Zusanli (ST36) was destroyed by injection of type I collagenase, the needle force caused by the acupuncture declined and the analgesic effects of rotation or lift-thrusting manipulations was attenuated accompanying the restraint of the degranulation ratios of mast cells. We propose that collagen fibers play an important role in acupuncture-induced analgesia, and they participate in signal transmission and transform processes.
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