期刊
CONNECTIVE TISSUE RESEARCH
卷 49, 期 2, 页码 68-75出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03008200801913502
关键词
bone; extracellular matrix; fibrillar collagens; mineralization; osteoblasts
资金
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR038648, R37AR038648] Funding Source: NIH RePORTER
- NIAMS NIH HHS [AR-38648] Funding Source: Medline
Collagen XXIV is an ill-characterized fibrillar collagen that is predominantly expressed in the forming skeleton of the mouse embryo. Here we report that the Col24al gene is constitutively transcribed in the trabecular bone and periosteum of the newborn mouse as well. The bone specificity of Col24al was further documented using three well-characterized cell culture models of osteoblast differentiation. These in vitro analyses indicated that Col24al transcription is activated at about the same time as that of the osteocalcin gene, and gradually increases to eventually plateau as osteoblasts begin to deposit a mineralizing matrix. These findings lend further support to the hypothesis that collagen XXIV may be implicated in the formation of a mineralization-competent bone matrix.
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