期刊
CONNECTIVE TISSUE RESEARCH
卷 49, 期 3-4, 页码 140-144出版社
INFORMA HEALTHCARE
DOI: 10.1080/03008200802148595
关键词
glycosaminoglycans; heparin; heparan sulfate; sequence; structure; conformation
资金
- MRC [G0200629] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Medical Research Council [G0200629] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
The glycosaminoglycan heparan sulfate (HS), is expressed on the surface of virtually all mammalian cells and is implicated in many crucial biological activities. The activities of HS and its close structural analogue heparin are mediated through interactions with proteins. However, the relationship between structure and activity is not simple, because the structure and conformation of HS and heparin are complex. This review surveys some of the relevant findings in HS/heparin chemistry, biochemistry, and biology.
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