期刊
CONGENITAL ANOMALIES
卷 52, 期 2, 页码 97-103出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1741-4520.2012.00359.x
关键词
angiogenesis-related factor; inflammatory cytokine; placenta; preeclampsia; umbilical vessel
类别
资金
- Grants-in-Aid for Scientific Research [22501006, 24659869] Funding Source: KAKEN
We hypothesized that gene expression in placenta and umbilical vessels are affected by intrauterine environment and some of the expression in umbilical vessels originating from the fetus could reflect fetal condition of these complicated pregnancies. Expression of angiogenesis-related factors and inflammatory cytokines were examined in placenta and umbilical vessels to clarify the effects of intrauterine environment of pregnancies complicated by preeclampsia and chorioamnionitis/funisitis. Forty-six preterm cesarean section deliveries were classified into three groups based on maternal condition during prenatal monitoring: preeclampsia (PE) (n = 11), chorioamnionitis/funisitis (CAM) (n = 8), and preterm control (PC) (n = 27). Angiogenesis-related factors and inflammatory cytokines in placentas, umbilical arteries and umbilical veins were analyzed by RT-PCR and immunohistochemistry. We demonstrated that Ang-2, Tie-2, and Dll4 increase in the placentas of PE compared to PC for the first time, and we confirmed the findings of previous reports showing the high expression of HIF-1a, sFlt-1, endoglin, leptin, and AT1R. Expression of angiogenesis-related factors, including HIF-1a, VEGF, angiopoietin, and TGF-beta systems, and inflammatory cytokines, such as TNF-a and IL-6, increased in umbilical vessels of PE. Umbilical veins of CAM showed a higher Dll4 level than did PC. In preeclampsia, abnormal expressions of angiogenesis-related factors related to lifestyle diseases in adulthood were seen in the placenta and umbilical vessels as compared to PC. Chorioamnionitis/funisitis showed only upregulation of DII4 in umbilical veins.
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