期刊
JOURNAL OF MOLECULAR MEDICINE-JMM
卷 93, 期 10, 页码 1061-1073出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-015-1326-7
关键词
mTOR; Health; TOR; mTORCI; mTORC2; mTOR inhibitors; Rapamycin; Rapalogs; Disease
资金
- Swiss National Science Foundation
- NCCR RNA and Disease Grant
Target of rapamycin (TOR) is a highly conserved protein kinase that plays a key role in mediating cell growth and homeostasis. It is activated by nutrients, growth factors, and cellular energy levels to control a number of anabolic and catabolic processes. It is a validated drug target implicated in a variety of diseases. In this review, we describe the molecular mode of action of TOR in the context of cellular and organismal physiology. We focus on mammalian TOR (mTOR) signaling in cancer and neurological disease and discuss usage of TOR inhibitors in the clinic.
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