Simulating the Electro-Mechanical Behavior of Skeletal Muscles

Computational models of the human body must be accurate enough to use in hypothesis testing or biological function analysis. This is possible only when such models use physiological information from different scales-such as the cell, tissue, and organ levels. This model of excitation-contraction coupling in skeletal muscles links cell-level electro-physiological behavior with organ-level biomechanical behavior.