期刊
COMPUTERS IN BIOLOGY AND MEDICINE
卷 53, 期 -, 页码 19-29出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2014.05.007
关键词
Systems pharmacology; Addition and subtraction theory; Da chaihu decoction; Xiao chaihu decoction; Traditional Chinese medicine
类别
资金
- Northwest AF University
- National Natural Science Foundation of China [31170796, 81373892]
- Special Research Foundation for Traditional Chinese Medicine [200907001-5]
Background: Addition and subtraction theory (AST), a basic theory of herb combination in traditional Chinese medicine (TCM), is often used to add or subtract the fundamental formulae to generate more targeted prescriptions. This theory plays a core role in individualized medicine and compound compatibility of TCM. However, the mechanisms underlying AST have largely remained elusive. Methods: An integrated platform of systems pharmacology was proposed for revealing how the oral administration, drug half-life, and target interactions affect the pharmacological functions of herbal medicines. This platform was further applied on two classical prescriptions, i.e., Xiao Chaihu decoction (XCHD) and Da Chaihu decoction (DCHD) to dissect the addition and subtraction theory (AST). Results: We uncovered the candidate compounds, key molecular targets and interaction network involved in XCHD and DCHD, and summarized its pharmacological characters and therapeutic indications. The results show that the fundamental formula is responsible for the major therapeutic effects, whereas the additive herbs synergistically enhance the treatment outcomes by targeting the same or complementary proteins between the foundational and additive herbs. Conclusion: This work has established a novel method to comprehensively understand the mechanism of AST, which would be beneficial for the TCM recipe optimization as well as the production of new herbal formula with desirable therapeutic effects. (C) 2014 Elsevier Ltd. All rights reserved.
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