期刊
COMPUTERS IN BIOLOGY AND MEDICINE
卷 42, 期 3, 页码 290-297出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2011.02.007
关键词
Cardiovascular interactions; Conditional entropy; Granger causality; Multivariate time series; Time delay embedding
The complexity of the short-term cardiovascular control prompts for the introduction of multivariate (MV) nonlinear time series analysis methods to assess directional interactions reflecting the underlying regulatory mechanisms. This study introduces a new approach for the detection of nonlinear Granger causality in MV time series, based on embedding the series by a sequential, non-uniform procedure, and on estimating the information flow from one series to another by means of the corrected conditional entropy. The approach is validated on short realizations of linear stochastic and nonlinear deterministic processes, and then evaluated on heart period, systolic arterial pressure and respiration variability series measured from healthy humans in the resting supine position and in the upright position after head-up tilt. (C) 2011 Elsevier Ltd. All rights reserved.
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