期刊
COMPUTERS IN BIOLOGY AND MEDICINE
卷 41, 期 12, 页码 1100-1109出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2011.07.008
关键词
Cortico-cortical evoked potentials; Diffusion-weighted MRI; Broca's area; Connectivity; Epilepsy; Intracranial stimulation; Language; Phonation; Articulation; Arcuate fasciculus
类别
资金
- National Institutes of Health [KL2 RR0224149]
- Vivian Smith Foundation for Neurologic Research
- Epilepsy Foundation
Here we present a novel multimodal analysis of network connectivity in the language system. We assessed connectivity of Broca's area using tractography with diffusion tensor imaging (DTI), and with cortico-cortical evoked potentials (CCEPs) to measure the spread of artificial currents applied directly to human cortex. We found that both the amplitude and latency of CCEP currents significantly correlates (r(2)=0.41, p < 10(-16)) with the number of DTI pathways connecting the stimulation and recording loci. This strategy of relating electrical information flow with the neural architecture will likely yield new insights into cognitive processes. (C) 2011 Elsevier Ltd. All rights reserved.
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