期刊
ANIMAL GENETICS
卷 47, 期 1, 页码 28-35出版社
WILEY
DOI: 10.1111/age.12377
关键词
differentially expressed genes; hypoxia adaptation; transcriptome; yak
资金
- National Natural Science Foundation of China [31200946, 31322052]
- National High Technology Research and Development Program of China [2013AA102505 3-2]
- Fundamental Research Funds for the Central Universities [lzujbky-2012-112, lzujbky-2013-205]
- Lanzhou University
DNA sequence variation has been widely reported as the genetic basis for adaptation, in both humans and other animals, to the hypoxic environment experienced at high altitudes. However, little is known about the patterns of gene expression underlying such hypoxic adaptations. In this study, we examined the differences in the transcriptomes of four organs (heart, kidney, liver and lung) between yak and cattle, a pair of closely related species distributed at high and low altitudes respectively. Of the four organs examined, heart shows the greatest differentiation between the two species in terms of gene expression profiles. Detailed analyses demonstrated that some genes associated with the oxygen supply system and the defense systems that respond to threats of hypoxia are differentially expressed. In addition, genes with significantly differentiated patterns of expression in all organs exhibited an unexpected uniformity of regulation along with an elevated frequency of nonsynonymous substitutions. This co-evolution of protein sequences and gene expression patterns is likely to be correlated with the optimization of the yak metabolic system to resist hypoxia.
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